Changing facades of Vibrio cholerae: An enigma in the epidemiology of cholera

Cholera, caused by the Gram-negative bacterium Vibrio cholerae, has ravaged humanity from time immemorial. Although the disease can be treated using antibiotics along with administration of oral rehydration salts and controlled by good sanitation, cholera is known to have produced mayhems in ancient times when little was known about the pathogen. By the 21st century, ample information about the pathogen, its epidemiology, genetics, treatment and control strategies was revealed. However, there is still fear of cholera outbreaks in developing countries, especially in the wake of natural calamities. Studies have proved that the bacterium is mutating and evolving, out-competing all our efforts to treat the disease with previously used antibiotics and control with existing vaccines. In this review, the major scientific insights of cholera research are discussed. Considering the important role of biofilm formation in the V. cholerae life cycle, the vast availability of next-generation sequencing data of the pathogen and multi-omic approach, the review thrusts on the identification of suitable biofilm-inhibiting targets and the discovery of anti-biofilm drugs from nature to control the disease.

Relationship between body mass index and knee alignment using non-radiographic / umbilical method.

Aim: The aim of the research was to investigate the relationship between body mass index and knee alignment angle using non-radiographic methods, and to propose a regression equation to define the relationship.Method: A total of 300 students (200 males, 100 females) of Nnamdi Azikiwe University, Nnewi campus participated in the study. Knee alignment was measured using body landmarks (umbilicus, right knee and right second toe) with a goniometer and calliper; the body mass index was also determined.Result: The male subjects had a mean body mass index of 24.2 kg/m2 and knee alignment angle of 176.5o. The female participants had a mean body mass index of 22.7 kg/m2 and knee alignment angle of 180.9o. Body mass index had no significant relationship with knee alignment in both males and females respectively (r = 0.009, p > 0.05; r = 0.065, p > 0.05). Conclusion: The study showed no significant positive relationship between body mass index and knee alignment, and body mass index is therefore not a good determinant for the control of knee alignment-based knee osteoarthritis.

Virtual Surgical Planning and Stereolithography-guided Osteotomy for 3 Dimensional Mandibular Reconstruction with Free Fibula Osseous Flaps: A Case Report

Lymphangiogenesis, lymphatic endothelial cells and lymphatic metastasis in head and neck cancer--a review of mechanisms / 国际口腔科学杂志·英文版

Lymphatic metastasis is a continuous and complicated process. The detailed mechanisms of lymphatic metastasis are still not very clear, despite considerable research efforts in recent years. Previously, it was commonly accepted that there were no lymphatic vessels in the primary tumor. However, recent studies have demonstrated that lymphatic vessels are detectable in certain types of cancer, and more and more evidence has shown that cancer cells invade into local lymph nodes mainly via peritumoral lymphatic vessels. Moreover, activated endothelial cells may also be important, having an influence on lymphatic metastasis of cancer cells. This article, based on recent research findings, provides an in-depth discussion of the relationship between lymphangiogenesis, tumor-derived lymphatic endothelial cells and lymphatic metastasis in head and neck cancer.

Effect of acute heat stress on certain immunological parameters in albino rats.

The effect of acute heat stress on certain immunological parameters were studied in male albino rats. The test rats were exposed to an ambient temperature of 40 degrees celsius for 30 minutes and sacrificed immediately. Total WBC count, Differential count, Phagocytic index, NBT reduction, organ weight body weight ratio of spleen, thymus, and popliteal lymph nodes, and soluble immune complex levels were measured in control group and the heat stressed animals. The heat stressed animals show decrease in total WBC count, and neutrophilia, eosinophilia, and lymphocytopenia. The phagocytic index showed a significant increase whereas the avidity index showed a decrease from the control value. NBT reduction was also significant. The soluble immune complex level was not altered. The heat stressed animals showed a decrease in the thymus and spleen weight/body weight ratio while the lymph node/body weight ratio showed an increase compared to the control animals.